Mechanisms of collective cell movement lacking a leading or free front edge in vivo

Hiroyuki Uechi, Erina Kuranaga

    研究成果: Review article査読

    2 被引用数 (Scopus)


    Collective cell movement is one of the strategies for achieving the complex shapes of tissues and organs. In this process, multiple cells within a group held together by cell–cell adhesion acquire mobility and move together in the same direction. In some well-studied models of collective cell movement, the mobility depends strongly on traction generated at the leading edge by cells located at the front. However, recent advances in live-imaging techniques have led to the discovery of other types of collective cell movement lacking a leading edge or even a free edge at the front, in a diverse array of morphological events, including tubule elongation, epithelial sheet extension, and tissue rotation. We herein review some of the developmental events that are organized by collective cell movement and attempt to elucidate the underlying cellular and molecular mechanisms, which include membrane protrusions, guidance cues, cell intercalation, and planer cell polarity, or chirality pathways.

    ジャーナルCellular and Molecular Life Sciences
    出版ステータスPublished - 2017 8 1

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology
    • Pharmacology
    • Cellular and Molecular Neuroscience
    • Cell Biology

    フィンガープリント 「Mechanisms of collective cell movement lacking a leading or free front edge in vivo」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。