Mechanisms in remodeling of the kidney

Masaomi Nangaku, Toshio Miyata

研究成果: Review article

抜粋

Representative remodeling of the kidney in CKD includes development of glomerulosclerosis and tubulointerstitial fibrosis. Injury to glomerular endothelium, mesangium, or podocyte can induce glomerulosclerosis, although recent studies have focused on a role of podocytes due to its lack of proliferation. Development of tubulointerstitial fibrosis is multi-factorial, and includes proteinuria, chronic hypoxia, activation of the intra-renal renin-angiotensin system, imbalance of matrix production and protease activity, and epithelial-mesenchymal transdifferentiation. Optimal remodeling may induce restoration of normal kidney structure, and some potential candidates of resident renal stem cells have been proposed. Development of therapeutic approaches targeting final common pathways will open a new avenue in management of patients with CKD.

元の言語English
ページ(範囲)1696-1700
ページ数5
ジャーナルNippon rinsho. Japanese journal of clinical medicine
66
発行部数9
出版物ステータスPublished - 2008 9
外部発表Yes

ASJC Scopus subject areas

  • Medicine(all)

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