Mechanism of the inhibitory action of cyclooxygenase inhibitors on leukocyte infiltration: Involvement of endogenous histamine

Noriyasu Hirasawa, Kazuo Ohuchi, Masako Watanabe, Susumu Tsurifuji

研究成果: Article査読

15 被引用数 (Scopus)

抄録

The mechanism of the inhibitory action of cyclooxygenase inhibitors on leukocyte accumulation in the inflammatory locus was investigated in an allergic inflammation of the air pouch types in rats. Three kinds of cyclooxygenase inhibitors, indomethacin, diclofenac and tiaprofenic acid, caused not only inhibition of the vascular permeability response and leukocyte accumulation but also elevation of histamine levels in the exudate. These effects of indomethacin were all reversed by local administration of prostaglandin E2. Pyrilamine, an H1 antagonist, did not affect the anti-inflammatory actions of indomethacin. The H2 antagonists, cimetidine, ranitidine and famotidine, decreased the inhibitory effect of indomethacin on leukocyte accumulation without affecting the inhibitory action on vascular permeability. These results indicate that the inhibitory action of cyclooxygenase inhibitors on leukocyte accumulation is derived from their blocking effect against generation of PGE2 which works as an inhibitory factor on the production of histamine in the inflammatory tissues.

本文言語English
ページ(範囲)267-275
ページ数9
ジャーナルEuropean Journal of Pharmacology
144
3
DOI
出版ステータスPublished - 1987 12 15

ASJC Scopus subject areas

  • Pharmacology

フィンガープリント 「Mechanism of the inhibitory action of cyclooxygenase inhibitors on leukocyte infiltration: Involvement of endogenous histamine」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル