Mechanism of sequential order determination in bio-raman correlation analysis

Sota Takanezawa, Yasushi Sako, Yukihiro Ozaki, Shin Ichi Morita

研究成果: Conference contribution

5 被引用数 (Scopus)


Using the measured Raman spectra of triolein and cholesteryl linolenate, the contradiction caused in determining the sequential orders in the two-dimensional correlation spectroscopy was exemplified, in which time-profiles of four marker bands A, B, C, and D were modeled so that A→B→C→ D. Here 'A→B' is such notation that we read as 'A is occurred before B' or 'A earlier than B'. The two-dimensional correlation method gave the result B→C→D→A which was contradictive to the initial setting. We confirmed that the increments of distance between the peak positions of the Gaussian type time-profiles f and g, through a threshold, gave the unexpected switch in the sequential order. On the complex plane based on the synchronous and asynchronous axes, the vector g is identical to the synchronous axis in direction; the vector f is crossed through the asynchronous axis corresponding to the increments of distance between the peak positions of f and g. By the conventional rule of the correlation method, the vector f just crossing the asynchronous axis is not allowed to be in the second quadrant, but the vector f is transformed to the fourth quadrant with 180 degrees shifted. In the situation, the vector f is located in the later position for the standard vector g, that is, f is occurred 'after' g. Based on the revealed mechanism for the contradiction, the time series correlation analysis may be extended in a more versatile manner to allow bio-Raman correlation analysis on diverse dynamics of bio-molecules in living cells.

ホスト出版物のタイトルNano-Bio Sensing, Imaging, and Spectroscopy
出版ステータスPublished - 2013 9 17
イベントSPIE Nano-Bio Sensing, Imaging, and Spectroscopy - Jeju, Korea, Republic of
継続期間: 2013 2 202013 2 23


名前Proceedings of SPIE - The International Society for Optical Engineering


ConferenceSPIE Nano-Bio Sensing, Imaging, and Spectroscopy
CountryKorea, Republic of

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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