Mechanism of Macrophage Fungicidal Activity Against Cryptococcus neoformans: A Comparative Study Between Mouse and Human

研究成果: Article査読

抄録

Host defense against infection with Cryptococcus neoformans is mediated by cellular immunity and macrophages play a central role in the elimination of organisms. To acquire effective microbicidal activity, macrophages need to be stimulated by interferon (IFN)-γ, which is produced by NK cells, γ T cells and helper T cells. There are two major systems, reactive oxygen and nitrogen reactive intermediates, in the macrophage killing of microbial pathogens. This review focuses on the roles of these mediators in cryptococcocidal activity of macrophages and compares mouse and human macrophages by describing our experimental results.

本文言語English
ページ(範囲)233-238
ページ数6
ジャーナルJapanese Journal of Medical Mycology
38
3
DOI
出版ステータスPublished - 1997

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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