Mechanical stress induces the activation of TAK1 and its downstream pathways in pre-osteoblastic cells

Naoto Fukuno, Hiroyuki Matsui, Osamu Suzuki, Keiichi Sasaki, Takayasu Kobayashi, Shinri Tamura

研究成果: Conference contribution

抄録

Mechanical stress plays an essential role in bone homeostasis by regulationg both bone formation and resorption. We have previously shown that cyclic stretch loading to MC3T3-E1 cells induced the expression of two bone remodeling related genes, Fn14 and MCP-3, through activation of ASK1 (a MAPKKK)/JNK and ASK1/p38 pathways, respectively. Here we show that cyclic stretch loading also induced the activation of TAK1 (another MAPKKK). Using TAK1 specific inhibitor 5Z-7 oxozeaenol, we revealed that TAK1 was required for the activation of at least four downstream pathways, namely, JNK, p38, NF-κB and NLK pathways. Moreover, TAK1 is activated via Ca2+-CaMKII pathway, resembling the non-canonical Wnt signaling pathway. These observations raise the possibility that TAK1 also plays various essential roles in mechanical stess-induced bone remodeling by activating diverse downstream pathways.

本文言語English
ホスト出版物のタイトル20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science
ページ383-384
ページ数2
DOI
出版ステータスPublished - 2009 12 1
イベント20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science - Nagoya, Japan
継続期間: 2009 11 82009 11 11

出版物シリーズ

名前20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science

Other

Other20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science
CountryJapan
CityNagoya
Period09/11/809/11/11

ASJC Scopus subject areas

  • Computer Science(all)
  • Control and Systems Engineering
  • Electrical and Electronic Engineering

フィンガープリント 「Mechanical stress induces the activation of TAK1 and its downstream pathways in pre-osteoblastic cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル