Measurement of the ratio of cerebral oxygen consumption to glucose utilization by positron emission tomography: Its consistency with the values determined by the Kety-Schmidt method in normal volunteers

J. Hatazawa, M. Ito, T. Matsuzawa, T. Ido, S. I. Watanuki

研究成果: Article査読

20 被引用数 (Scopus)

抄録

The regional relationship between cerebral oxygen consumption (CMRO2) and cerebral glucose utilization (CMRGlc) was studied in normal subjects using positron emission tomography (PET) and the 15O steady-state inhalation and the [18F]fluoro deoxyglucose method. The use of standard sets of rate constants and the model lumped constant of 0.52 as well as the regional blood-brain partition coefficient for water and the blood volume correction for oxygen extraction fraction provided a CMRO2/CMRGcl ratio of 4.89 in the cortical gray matter, 5.27 in the basal ganglia and 5.82 in the centrum semiovale (white matter). The values of CMRO2/CMRGlc for the basal ganglia and the white matter were consistent with those reported for the whole brain with the Kety-Schmidt method. There was no significant difference in the CMRO2/CMRGlc between the basal ganglia and the white matter indicating the similar nature of in vivo oxidative metabolism of glucose in neuron-rich region and glial cell-rich region.

本文言語English
ページ(範囲)426-432
ページ数7
ジャーナルJournal of Cerebral Blood Flow and Metabolism
8
3
DOI
出版ステータスPublished - 1988

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学
  • 循環器および心血管医学

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