Measurement of lysophospholipase D/autotaxin activity in human serum samples

Kazuhiro Nakamura, Ryunosuke Ohkawa, Shigeo Okubo, Minoru Tozuka, Mitsumasa Okada, Shinya Aoki, Junken Aoki, Hiroyuki Arai, Hitoshi Ikeda, Yutaka Yatomi

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Objectives: Lysophospholipase D (lysoPLD)/autotaxin regulates the blood levels of lysophosphatidic acid (LPA), and we designed a serum lysoPLD assay for use in clinical laboratory testing. Design and methods: LysoPLD activity was assessed based on the amount of choline released with lysophosphatidylcholine as the substrate. Results and conclusions: It was confirmed that the lysoPLD assay can be applied to clinical laboratory testing. The serum lysoPLD activity in healthy female subjects was significantly higher than that in the male subjects.

本文言語English
ページ(範囲)274-277
ページ数4
ジャーナルClinical Biochemistry
40
3-4
DOI
出版ステータスPublished - 2007 2 1
外部発表はい

ASJC Scopus subject areas

  • Clinical Biochemistry

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