Measurement of infinitesimal phase response curves from noisy real neurons

Keisuke Ota, Toshiaki Omori, Shigeo Watanabe, Hiroyoshi Miyakawa, Masato Okada, Toru Aonishi

研究成果: Article査読

13 被引用数 (Scopus)

抄録

We sought to measure infinitesimal phase response curves (iPRCs) from rat hippocampal CA1 pyramidal neurons. It is difficult to measure iPRCs from noisy neurons because of the dilemma that either the linearity or the signal-to-noise ratio of responses to external perturbations must be sacrificed. To overcome this difficulty, we used an iPRC measurement model formulated as the Langevin phase equation (LPE) to extract iPRCs in the Bayesian scheme. We then simultaneously verified the effectiveness of the measurement model and the reliability of the estimated iPRCs by demonstrating that LPEs with the estimated iPRCs could predict the stochastic behaviors of the same neurons, whose iPRCs had been measured, when they were perturbed by periodic stimulus currents. Our results suggest that the LPE is an effective model for real oscillating neurons and that many theoretical frameworks based on it may be applicable to real nerve systems.

本文言語English
論文番号041902
ジャーナルPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
84
4
DOI
出版ステータスPublished - 2011 10 3

ASJC Scopus subject areas

  • 統計物理学および非線形物理学
  • 統計学および確率
  • 凝縮系物理学

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