Mathematical models of regulatory mechanisms of sleep-wake rhythms

M. Nakao, Akihiro Karashima, Norihiro Katayama

研究成果: Review article査読

7 被引用数 (Scopus)

抄録

Studies of regulatory mechanisms of sleep-wake rhythms have benefited greatly from mathematical modeling. There are two major frameworks of modeling: one integrates homeostatic and circadian regulations and the other consists of multiple interacting oscillators. In this article, model constructions based on these respective frameworks and their characteristics are reviewed. The two-process model and the multioscillator model are explained in detail. An appropriate mathematical abstraction is also shown to provide a viewpoint unifying the model structures, which might seem to be distinct. Recently acquired knowledge of neural regulatory mechanisms of sleep-wake rhythm has prompted modeling at the neural network level. Such a detailed model is also reviewed, and could be used to explore a possible neural mechanism underlying a pathological state of sleep-wake rhythm.

本文言語English
ページ(範囲)1236-1243
ページ数8
ジャーナルCellular and Molecular Life Sciences
64
10
DOI
出版ステータスPublished - 2007 5

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学
  • 薬理学
  • 細胞および分子神経科学
  • 細胞生物学

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