Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice

Yasushi Ishijima, Shin'ya Ohmori, Kinuko Ohneda

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Mast cells have been suggested to play key roles in adipogenesis. We herein show that the expression of preadipocyte, but not adipocyte, marker genes increases in the white adipose tissue of mast cell-deficient (KitW-sh/W-sh) mice under both obese and non-obese conditions. In vitro culturing with adipogenic factors revealed increased adipocytes differentiated from the KitW-sh/W-sh stromal vascular fraction, suggesting the accumulation of preadipocytes. Moreover, the increased expression of preadipocyte genes was restored by mast cell reconstitution in the KitW-sh/W-sh mice. These results suggest positive effects of mast cells on the preadipocyte to adipocyte transition under both physiological and pathological conditions.

本文言語English
ページ(範囲)18-24
ページ数7
ジャーナルFEBS Open Bio
4
DOI
出版ステータスPublished - 2014
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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