TY - JOUR
T1 - Mass spectrometry for chemical diagnosis and pharmaceutical care
AU - Mano, Nariyasu
AU - Simada, Miki
AU - Goto, Junichi
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Recently, mass spectrometry is expected to be big contributors in clinical practice. Especially, proteomics and metabolomics for searching disease biomarkers and new drug target molecules are now attracting attention, and the researches on the subjects including method developments are doing actively. Meanwhile, mass spectrometry coupled with chromatography has been already used for chemical diagnosis and therapeutic drug monitoring in pharmaceutical care, and its coverage is rapidly expanding combined with recent progress of method and biotechnology. In this article, we focused chemical diagnosis and pharmaceutical care mainly, and consider a future direction of clinical application of mass spectrometry with organizing its present problem.
AB - Recently, mass spectrometry is expected to be big contributors in clinical practice. Especially, proteomics and metabolomics for searching disease biomarkers and new drug target molecules are now attracting attention, and the researches on the subjects including method developments are doing actively. Meanwhile, mass spectrometry coupled with chromatography has been already used for chemical diagnosis and therapeutic drug monitoring in pharmaceutical care, and its coverage is rapidly expanding combined with recent progress of method and biotechnology. In this article, we focused chemical diagnosis and pharmaceutical care mainly, and consider a future direction of clinical application of mass spectrometry with organizing its present problem.
KW - Electrospray ionization
KW - Liquid chromatography/tandem mass spectrometry
KW - Matrix-assisted laser desorption/ionization
KW - Newborn mass screening
KW - Therapeutic drug monitoring
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M3 - Article
AN - SCOPUS:77349120513
VL - 39
SP - 70
EP - 78
JO - Japanese Journal of Clinical Chemistry
JF - Japanese Journal of Clinical Chemistry
SN - 0370-5633
IS - 1
ER -