Marked increase in [3H](R) α-methylhistamine binding in the superior colliculus of visually deprived rats after unilateral enucleation

Yoichi Nakagawa, Kazuhiko Yanai, Jong Hoon Ryun, Motohiro Kiyosawa, Makoto Tamai, Takehiko Watanabe

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The binding of [3H](R)α-methylhistamine to histamine H3-receptors in visual structures of unilaterally enucleated rats was examined by quantitative autoradiography to clarify the involvement of histamine neurons in the visual system. [3H](R)α-Methylhistamine binding in the visually deprived superior colliculus, contralateral to the enucleated eye, was significantly increased 5, 15, 30 and 45 days after unilateral enucleation. Slight time-dependent increases in ligand binding were observed in the visual cortex, but the change was significant only 45 days after unilateral enucleation. Unilateral enucleation had no significant effect in the dorsal lateral geniculate nucleus at any time after enucleation. Continuous injection of (S)-α-fluoromethylhistidine, a specific inhibitor of l-histidine decar{ballot box}ylase, attenuated the effect of unilateral enucleation in the superior colliculus. These results suggest that retinal deafferentation induced an increase in histamine H3-receptor binding sites, probably by selective adjustment of histamine neurons in response to unilateral enucleation.

本文言語English
ページ(範囲)74-80
ページ数7
ジャーナルBrain research
643
1-2
DOI
出版ステータスPublished - 1994 4 18

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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