TY - JOUR
T1 - Marked improvement of delayed methotrexate-induced leukoencephalopathy treated with high-dose folinic acid
AU - Hasegawa, T.
PY - 1997
Y1 - 1997
N2 - We report the case of a patient with delayed methotrexate (MTX)-induced leukoencephalopathy who showed a marked improvement both in clinical and neuroimaging findings after a high-dose of the active form of folinic acid (leucovorin) treatment. The patient developed progressive affective impairment accompanied by headache, nausea and vomiting after treatment with MTX during the chemotherapy for acute lymphoblastic leukemia, and diagnosed as delayed type MTX-induced leukoencephalopathy. After an intravenous injection of high-dose folinic acid (total 1920 mg), neurological deficits and white matter changes dramatically improved in a few weeks. Although delayed MTX-induced leukoencephalopathy may cause irreversible brain damage, an early treatment with high dose leucovorin may thus facilitate the marked improvement of clinical findings and white matter abnormalities.
AB - We report the case of a patient with delayed methotrexate (MTX)-induced leukoencephalopathy who showed a marked improvement both in clinical and neuroimaging findings after a high-dose of the active form of folinic acid (leucovorin) treatment. The patient developed progressive affective impairment accompanied by headache, nausea and vomiting after treatment with MTX during the chemotherapy for acute lymphoblastic leukemia, and diagnosed as delayed type MTX-induced leukoencephalopathy. After an intravenous injection of high-dose folinic acid (total 1920 mg), neurological deficits and white matter changes dramatically improved in a few weeks. Although delayed MTX-induced leukoencephalopathy may cause irreversible brain damage, an early treatment with high dose leucovorin may thus facilitate the marked improvement of clinical findings and white matter abnormalities.
KW - Acute lymphoblastic leukemia (ALL)
KW - High-dose folinic acid
KW - Leukoencephalopathy
KW - MTX neurotoxicity
UR - http://www.scopus.com/inward/record.url?scp=0030830229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030830229&partnerID=8YFLogxK
U2 - 10.1111/j.1468-1331.1997.tb00395.x
DO - 10.1111/j.1468-1331.1997.tb00395.x
M3 - Article
AN - SCOPUS:0030830229
VL - 4
SP - 517
EP - 520
JO - European Journal of Neurology
JF - European Journal of Neurology
SN - 1351-5101
IS - 5
ER -