Manganese salen complexes with acid-base catalytic auxiliary: Functional mimetics of catalase

Yukinobu Noritake, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi

研究成果: Article査読

42 被引用数 (Scopus)


Antioxidant therapies have been considered for a wide variety of disorders associated with oxidative stress, and synthetic catalytic scavengers of reactive oxygen species would be clinically superior to stoichiometric ones. Among them, salen-manganese complexes (Mn(Salen)) seem promising, because they exhibit dual functions, i.e. superoxide dismutase- and catalase-mimetic activities. We have been developing enzyme-mimetic Mn(Salen) complexes bearing a functional group that enhances their catalytic activity. Here, we describe the design and synthesis of novel Mn(Salen) complexes with general acid-base catalytic functionality, inspired by the reaction mechanism of catalase. As expected, these Mn(Salen) complexes showed superior catalase-like activity and selectivity, while retaining moderate SOD-like activity. An unsubstituted pyridyl group worked well as a functionality to promote catalase-like activity. The introduced functionality did not alter the redox potential suggesting that the auxiliary-modified complex acted as an acid-base catalyst analogous to catalase. We believe that our approach provides a new design principle for sophisticated catalyst design. Further, the compounds described here appear to be good candidates for use in antioxidant therapy.

ジャーナルInorganic chemistry
出版ステータスPublished - 2013 4 1

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 無機化学


「Manganese salen complexes with acid-base catalytic auxiliary: Functional mimetics of catalase」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。