Management of pregnancy achieved by oocyte donation to a woman with 47, XXX and POF

Yusuke Shibuya, Yukihiro Terada, Jin Kumagai, Yukiyo Kumazawa, Masatoshi Saito, Tetsuro Hoshiai, Nobuo Yaegashi

研究成果: Article査読


[Objective] To present a case of pregnancy achieved by oocyte donation abroad to a woman with 47,XXX and premature ovarian failure (POF). [Patient(s)] A 39-year-old woman, gravida 0, para 0, with 47,XXX, POF and hypertension, achieved pregnancy by donation of oocytes abroad, and consulted us for pregnancy management. Dichorionic diamniotic twin fetuses were observed by ultrasonography, and gestational diabetes mellitus (GDM) occurred at 12 weeks of gestation. One of the twins was diagnosed with intrauterine growth restriction (IUGR) at 24 weeks of gestation. Uterine contraction was frequently observed at 28 weeks of gestation. Brain sparing effect was seen in the IUGR fetus at 30 weeks of gestation. The IUGR fetus presented a non-reassuring fetal status (NRFS) at 32 weeks of gestation, therefore twins were delivered by Caesarean section. [Results] Neonate 1 weighed 1,754 g with an Apgar score of 9/10 (1/5 minutes). Neonate 2 weighed 950 g with an Apgar score of 7/8. Both did well. While GDM improved in three weeks, the patient's hypertension persisted after delivery. [Conclusion] This kind of case will increase in Japan due to the emergence of middlemen for oocyte donations. To prepare for them, it is necessary to further investigate mechanisms of complications in pregnancies achieved with donated oocytes.

ジャーナルJournal of Mammalian Ova Research
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • 生殖医学
  • 細胞生物学


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