Magnetic Nanoparticle Detection by Utilizing Nonlinear Magnetization for Sentinel Lymph Nodes of Breast Cancer Patients

Akihiro Kuwahata, Kanae Taruno, Tomoko Kurita, Masujiro Makita, Shinichi Chikaki, Itsuro Saito, Hiroyuki Takei, Seigo Nakamura, Moriaki Kusakabe, Masaki Sekino

研究成果: Article査読

抄録

To minimize the invasiveness and improve the patient's quality of life, sentinel lymph node (SLN) biopsy with magnetic nanoparticles (MNPs) containing superparamagnetic iron oxide is performed on breast cancer patients. Identifying the first SLN by quantification of the amount of MNPs can help to investigate the cancer metastasis. We developed the device for performing iron quantification during surgery. The compact desktop-size device can be easily introduced into operation rooms, and simple system of the device enables identification of the first SLN. We investigated the optimum nonlinear magnetic responses that are attributed to magnetic relaxations under moderate small ac and dc magnetic fields (1 mT) and found that ac magnetic fields with < 5 kHz are effective in the detection of MNPs. In addition, our clinical trials revealed more iron ( 40μg ) in the first lymph node than in the second lymph node ( 10μg ), clearly indicating intraoperative quantification in the first node.

本文言語English
論文番号9145714
ジャーナルIEEE Transactions on Magnetics
57
2
DOI
出版ステータスPublished - 2021 2
外部発表はい

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 電子工学および電気工学

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