Macrodipole interaction of helical peptides in a self-assembled monolayer on gold substrate

Tsuhiko Fujita, Natascha Bunjes, Ken Nakajima, Masahiko Hara, Hiroyuki Sasabe, Wolfgang Knoll

    研究成果: Article査読

    56 被引用数 (Scopus)

    抄録

    Monolayers of helical peptides on gold substrates were prepared by a self-assembly approach aiming at fabricating a regular structure by the use of the specific interaction between neighboring helices. Two kinds of helical peptides were synthesized. One has a disulfide group at the N-terminal of the helix part, and the other, at the C-terminal of the same helix. Self-assembled monolayers (SAMs) were prepared by dipping a gold substrate into each peptide solution. The thickness and the molecular orientation of each monocomponent SAM indicated that the helical peptides were adsorbed on the surface with a preferred orientation parallel to the surface. However, those of an eqnimolar mixed SAM showed that the peptide took an appreciably vertical orientation on the surface. These observations indicated that an antiparallel helix packing is significantly more favorable than a parallel one. It is strongly suggested that the SAM structure is regulated by a dipolar interaction between helical peptides since the geometric fitting among the molecules in the parallel packing could be hardly different from that in the antiparallel packing.

    本文言語English
    ページ(範囲)6167-6172
    ページ数6
    ジャーナルLangmuir
    14
    21
    DOI
    出版ステータスPublished - 1998 10 13

    ASJC Scopus subject areas

    • Materials Science(all)
    • Condensed Matter Physics
    • Surfaces and Interfaces
    • Spectroscopy
    • Electrochemistry

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