Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174

Yuji Shinjo, Kumiko Makide, Keita Satoh, Fumiya Fukami, Asuka Inoue, Kuniyuki Kano, Yuko Otani, Tomohiko Ohwada, Junken Aoki

研究成果: Article

17 引用 (Scopus)

抜粋

Lysophosphatidylserine (LysoPS) has been shown to have lipid mediator-like actions to induce mast cell degranulation and suppress T lymphocyte proliferation. Recently, three G protein-coupled receptors (GPCRs), LPS1/GPR34, LPS2/P2Y10, and LPS3/GPR174, were found to react specifically with LysoPS, raising the possibility that LysoPS exerts its roles through these receptors. In this study, we show that LPS3 is expressed in various T cell subtypes and is involved in suppression of Interleukin-2 (IL-2) production in CD4 T cells. We found that LysoPS suppressed the IL-2 production from activated T cells at the mRNA and protein levels. In addition, LysoPS did not have such an effect on the splenocytes and CD4 T cells isolated from LPS3-deficient mice. In LPS3-deficient splenocytes and CD4 T cells, anti-CD3/anti-CD28-triggered IL-2 production is somewhat increased. Interestingly, LysoPS with various fatty acids was up-regulated upon T cell activation. The present study raised the possibility that LysoPS exerts its immunosuppressive roles by down-regulating IL-2 production through a LysoPS-LPS3 axis in T cells.

元の言語English
ページ(範囲)332-338
ページ数7
ジャーナルBiochemical and biophysical research communications
494
発行部数1-2
DOI
出版物ステータスPublished - 2017 12 9

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS<sub>3</sub>/GPR174' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用