Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: Novel therapeutic implications of targeting the channels by commonly used drugs

Itsuro Kazama, Tsutomu Tamada

研究成果: Review article査読

3 被引用数 (Scopus)

抄録

In patients with chronic obstructive pulmonary disease (COPD), over-activated T-lymphocytes produce pro-inflammatory cytokines and proliferate in situ in the lower airways and pulmonary parenchyma, contributing substantially to the pathogenesis of the disease. Despite our understanding of the molecular mechanisms by which lymphocytes are activated, we know little about the physiological mechanisms. T-lymphocytes predominantly express delayed rectifier K+-channels (Kv1.3) in their plasma membranes and these channels play crucial roles in inducing the lymphocyte activation and proliferation. In the pathogenesis of chronic inflammatory diseases, such as chronic kidney disease (CKD) or inflammatory bowel disease (IBD), these channels, which are overexpressed in proliferating lymphocytes within the inflamed organs, are responsible for the progression of the diseases. Since the over-activation of cellular immunity is also mainly involved in the pathogenesis of COPD, this disease could share similar pathophysiological features as those of CKD or IBD. From a literature review including ours, it is highly likely that the Kv1.3-channels are overexpressed or over-activated in T-lymphocytes isolated from patients with COPD, and that the overexpression of the channels would contribute to the development or progression of COPD. The involvement of the channels leads to novel therapeutic implications of potentially useful Kv1.3-channel inhibitors, such as calcium channel blockers, macrolide antibiotics, HMG-CoA reductase inhibitors and nonsteroidal anti-inflammatory drugs, in the treatment of COPD.

本文言語English
論文番号60
ジャーナルAllergy, Asthma and Clinical Immunology
12
1
DOI
出版ステータスPublished - 2016 11 29

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 呼吸器内科

フィンガープリント

「Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: Novel therapeutic implications of targeting the channels by commonly used drugs」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル