Lung C-fiber CNS reflex: Role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs

A. C. Bonham, C. Y. Chen, T. Mutoh, J. P. Joad

研究成果: Article

27 引用 (Scopus)

抜粋

Environmental tobacco smoke (ETS) exposure harms the respiratory health of children and is associated with an increased risk of asthma and sudden infant death syndrome (SIDS). The mechanisms by which ETS causes these effects are not understood. We hypothesized that one mechanism is an upregulation of the lung C-fiber central nervous system (CNS) reflex responses, which would result in exaggerated reflex responses of apnea, bronchoconstriction, and mucous hypersecretion. The purpose of this work is to highlight evidence obtained in an animal model of postnatal ETS exposure supporting the hypothesis and present data suggesting that actions of the neuropeptide substance P in the nucleus tractus solitarius (NTS) may contribute. Exposing young guinea pigs to sidestream smoke, the surrogate for ETS, for 5 weeks during the equivalent of human childhood, increased the excitability of afferent lung C fibers and NTS neurons in the CNS reflex pathway and prolonged the expiratory apnea. The findings suggest that an increased excitability of NTS neurons that can augment reflex output may contribute to respiratory symptoms in children exposed to ETS. Besides ETS exposure, substance P can also excite NTS neurons and augment lung C-fiber CNS reflex responses. Others have shown that substance P synthesis in lung C fibers is upregulated by another environmental stimulant, allergen. Thus, an upregulation of the substance P system at NTS synapses could contribute to the increased NTS excitability and enhanced reflex responses to lung C-fiber stimulation, providing a potential mechanism to help explain the association of ETS exposure with respiratory symptoms and SIDS.

元の言語English
ページ(範囲)573-578
ページ数6
ジャーナルEnvironmental health perspectives
109
発行部数SUPPL. 4
DOI
出版物ステータスPublished - 2001

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

フィンガープリント Lung C-fiber CNS reflex: Role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用