Low molecular weight dextran sulfate: A strong candidate drug to block IBMIR in clinical islet transplantation

H. Johansson, Masafumi Goto, A. Siegbahn, G. Elgue, O. Korsgren, B. Nilsson

研究成果: Article査読

93 被引用数 (Scopus)

抄録

The instant blood-mediated inflammatory reaction (IBMIR) is triggered in clinical islet transplantation when human pancreatic islets come in contact with blood and may explain the initial tissue loss associated with this procedure. Low molecular weight dextran sulfate (LMW-DS; MM 5000), today available for clinical use, inhibits both complement and coagulation activation. In a tubing loop model, LMW-DS at concentrations ranging from 0.01 to 1 g/L showed a dose-dependent inhibition of IBMIR with an inhibition of coagulation and complement activation and less consumption of platelets and other blood cells. In blood or plasma APTT was demonstrated to be an excellent method for monitoring the LMW-DS concentration both in vitro and in vivo in a nonhuman primate model. The toxicity was assessed using a glucose challenge test and the pharmacokinetics was tested in the nonhuman primate model. Here, we present a tentative protocol for using LMW-DS in clinical islet transplantation.

本文言語English
ページ(範囲)305-312
ページ数8
ジャーナルAmerican Journal of Transplantation
6
2
DOI
出版ステータスPublished - 2006 2 1

ASJC Scopus subject areas

  • 免疫学

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