Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: Changes in the risk for atherosclerotic diseases at various ages

Toshio Hayashi, Seinosuke Kawashima, Hideki Itoh, Nobuhiro Yamada, Hirohito Sone, Hiroshi Watanabe, Yoshiyuki Hattori, Takashi Ohrui, Koutaro Yokote, Hideki Nomura, Hiroyuki Umegaki, Akihisa Iguchi

    研究成果: Article査読

    30 被引用数 (Scopus)

    抄録

    OBJECTIVE - To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals. RESEARCH DESIGN AND METHODS - The Japan Cholesterol and Diabetes Mellitus Study is a prospective cohort study of 4,014 type 2 diabetic patients (1,936 women; mean ± SD age 67.4 ± 9.5 years). Lipid and glucose levels and other factors were investigated in relation to occurrence of IHD or CVD. RESULTS - IHD and CVD occurred in 1.59 and 1.43% of participants, respectively, over a 2-year period. The relation of lower HDL or higher LDL cholesterol to occurrence of IHD in subjects <65 years old was significant. Lower HDL cholesterol was also significantly related to CVD in subjects ≥65 years old and especially in those >75 years old (n = 1,016; odds ratio 0.511 [95% CI 0.239-0.918]; P < 0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed the same result. CONCLUSIONS - Lower HDL cholesterol is an important risk factor for not only IHD but also CVD, especially in diabetic elderly individuals.

    本文言語English
    ページ(範囲)1221-1223
    ページ数3
    ジャーナルDiabetes Care
    32
    7
    DOI
    出版ステータスPublished - 2009 7

    ASJC Scopus subject areas

    • 内科学
    • 内分泌学、糖尿病および代謝内科学
    • 高度および特殊看護

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