Loss of EGF-dependent cell proliferation ability on radioresistant cell HepG2-8960-R

Yohei Saito, Ryo Abiko, Akira Kishida, Yoshikazu Kuwahara, Yumi Yamamoto, Fumihiko Yamamoto, Manabu Fukumoto, Yasuhito Ohkubo

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Acquired radioresistance of cancer cells interferes with radiotherapy and increases the probability of cancer recurrence. HepG2-8960-R, which is one of several clinically relevant radioresistant (CRR) cell lines, has a high tolerance to the repeated clinically relevant doses of X-ray radiation. In this study, HepG2-8960-R had slightly lower cell proliferation ability than HepG2 in the presence of FBS. In particular, epidermal growth factor (EGF) hardly enhanced cell proliferation and DNA synthesis in HepG2-8960-R. Additionally, EGF could not induce the activation of Erk1/2, because the expression of EGF receptor (EGFR) protein decreased in HepG2-8960-R in accordance with the methylation of the EGFR promoter region. Therefore, cetuximab did not inhibit HepG2-8960-R cell proliferation. Our study showed that HepG2-8960-R had radioresistant and cetuximab-resistant abilities.

本文言語English
ページ(範囲)73-79
ページ数7
ジャーナルCell Biochemistry and Function
33
2
DOI
出版ステータスPublished - 2015 3 1

ASJC Scopus subject areas

  • 生化学
  • 臨床生化学
  • 細胞生物学

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