Loss of alleles at loci on chromosome 13 in human primary gastric cancers

Kazuyoshi Motomura, Isamu Nishisho, Sin ichiro Takai, Hideo Tateishi, Makoto Okazaki, Masayuki Yamamoto, Tetsuro Miki, Tasuku Honjo, Takesada Mori

研究成果: Article査読

61 被引用数 (Scopus)

抄録

Mitotic events leading to the loss of the normal allele corresponding to a mutated gene are important for tumorigenesis in rare heritable tumors such as retinoblastoma and Wilms tumor. As reported for both colorectal and breast cancers, some common tumors seem to develop because of the same mitotic events. We examined constitutional and tumor genotypes defined by polymorphic DNA clones in 36 patients with gastric cancer. In 14 cases, constitutional heterozygosity at loci on chromosome 13 had been lost. Loss of alleles was also detected at a locus on chromosome 18 in two cases and at a locus on chromosome 17 in one case. The frequent loss of alleles at loci on chromosome 13 (41%) suggests that elimination of genes on this chromosome may be of importance in the tumorigenesis of human primary gastric cancers.

本文言語English
ページ(範囲)180-184
ページ数5
ジャーナルGenomics
2
2
DOI
出版ステータスPublished - 1988 2
外部発表はい

ASJC Scopus subject areas

  • Genetics

フィンガープリント 「Loss of alleles at loci on chromosome 13 in human primary gastric cancers」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル