TY - JOUR
T1 - Longitudinal relationship between growth differentiation factor 11 and physical activity in chronic obstructive pulmonary disease
AU - Tanaka, Rie
AU - Koarai, Akira
AU - Yamada, Mitsuhiro
AU - Fujino, Naoya
AU - Ichikawa, Tomohiro
AU - Numakura, Tadahisa
AU - Onodera, Katsuhiro
AU - Kyogoku, Yorihiko
AU - Tamada, Tsutomu
AU - Miura, Motohiko
AU - Minakata, Yoshiaki
AU - Ichinose, Masakazu
AU - Sugiura, Hisatoshi
N1 - Funding Information:
W e thank Mr . Brent Bell for reading this manuscript. This study was supported by grants from the Japan Society for the Promotion of Science (grant number: #18K15916), a fund from the Japanese Respiratory Foundation, and supported by the Environmental Restoration and Conservation Agency of Japan.
Publisher Copyright:
© 2021 Tanaka et al.
PY - 2021
Y1 - 2021
N2 - Background: Daily physical activity is reduced in patients with chronic obstructive pulmonary disease (COPD) and a reduced level of physical activity has been shown to be an important predictor for the prognosis, such as increased risk of exacerbation and mortality. However, there has not yet been a useful biomarker of the physical activity. In our previous cross-sectional study, we showed that the level of one of the possible myokines, which is an anti-aging factor, growth differentiation factor 11 (GDF11), was decreased in the plasma from patients with COPD and correlated with the physical activity. To clarify this relation-ship, we conducted a longitudinal evaluation of such factors. Patients and Methods: Twenty-four COPD patients were enrolled and prospectively followed. We measured the levels of plasma GDF11 and systemic inflammatory markers with immunoblotting or ELISA, respectively. We also evaluated lung function and daily physical activity using a triaxial accelerometer and the incidence of exacerbation. Results: The change in the plasma level of GDF11, but not systemic inflammatory markers, was positively correlated with the change in the physical activity in an intensity-dependent manner (between the change in the number of steps and GDF11; r = 0.41, p = 0.047). In the multiple regression analysis, the relationship was confirmed (β = 0.93, p < 0.001). In addition, patients who maintained their plasma level of GDF11 showed a significantly lower incidence in exacerbations of COPD than those with decreased levels of GDF11 (p = 0.041). Conclusion: The longitudinal change in the plasma level of GDF11 was positively correlated with the change in the daily physical activity in COPD. GDF11 could be a useful humoral factor that reflects the physical activity in COPD.
AB - Background: Daily physical activity is reduced in patients with chronic obstructive pulmonary disease (COPD) and a reduced level of physical activity has been shown to be an important predictor for the prognosis, such as increased risk of exacerbation and mortality. However, there has not yet been a useful biomarker of the physical activity. In our previous cross-sectional study, we showed that the level of one of the possible myokines, which is an anti-aging factor, growth differentiation factor 11 (GDF11), was decreased in the plasma from patients with COPD and correlated with the physical activity. To clarify this relation-ship, we conducted a longitudinal evaluation of such factors. Patients and Methods: Twenty-four COPD patients were enrolled and prospectively followed. We measured the levels of plasma GDF11 and systemic inflammatory markers with immunoblotting or ELISA, respectively. We also evaluated lung function and daily physical activity using a triaxial accelerometer and the incidence of exacerbation. Results: The change in the plasma level of GDF11, but not systemic inflammatory markers, was positively correlated with the change in the physical activity in an intensity-dependent manner (between the change in the number of steps and GDF11; r = 0.41, p = 0.047). In the multiple regression analysis, the relationship was confirmed (β = 0.93, p < 0.001). In addition, patients who maintained their plasma level of GDF11 showed a significantly lower incidence in exacerbations of COPD than those with decreased levels of GDF11 (p = 0.041). Conclusion: The longitudinal change in the plasma level of GDF11 was positively correlated with the change in the daily physical activity in COPD. GDF11 could be a useful humoral factor that reflects the physical activity in COPD.
KW - Chronic obstructive pulmonary disease
KW - Exacerbation
KW - Growth differentiation factor 11
KW - Longitudinal study
KW - Physical activity
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U2 - 10.2147/COPD.S301690
DO - 10.2147/COPD.S301690
M3 - Article
C2 - 33883893
AN - SCOPUS:85104824460
VL - 16
SP - 999
EP - 1006
JO - International Journal of COPD
JF - International Journal of COPD
SN - 1176-9106
ER -