Long-term outcome of breast-conserving therapy for breast cancer

Akiko Shimauchi, Kenji Nemoto, Yoshihiro Ogawa, Yoshihisa Kakuto, Toru Sakayauchi, Yoshihiro Takai, Takanori Ishida, Noriaki Ohuchi, Hisashi Hirakawa, Michio Kimura, Takayuki Yamada, Shoki Takahashi, Shogo Yamada

研究成果: Article査読

5 被引用数 (Scopus)


Purpose: We present a retrospective analysis of long-term therapeutic results for patients treated in our institution to evaluate the efficacy of breast-conserving therapy (BCT). Patients and Methods: The study population was 99 patients (102 breasts) with stage 0, I, and II breast cancer who underwent breast conservation therapy between April 1990 and November 1997. The entire breast was irradiated to a median dose of 50 Gy (range, 50-60 Gy) in 25-30 fractions. An additional 10 Gy in five fractions with 6-12 MeV electrons was given to 23 breasts (23%) with positive surgical margins. Results: The 5-/10-year overall survival, cause-specific survival, relapse-free rate, local recurrence, and regional recurrence rates were 94.6/93.3%, 95.7/94.5%, 88.2/77.5%, 4.2/8.5%, and 2.0/6.3%, respectively. In both uni- and multivariate analyses, age < 40 years was a significant prognostic factor for local recurrence. No severe morbidity was observed. Conclusion: The long-term clinical outcome of BCT for early breast carcinoma patients in our department was favorable. Patient age <40 was the most important factor associated with an increased risk of local recurrence in the ipsilateral breast.

ジャーナルRadiation Medicine - Medical Imaging and Radiation Oncology
出版ステータスPublished - 2005 11

ASJC Scopus subject areas

  • 放射線
  • 放射線学、核医学およびイメージング
  • 腫瘍学


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