We studied the long-term outcome of deproteinised bone particles for augmentation of the maxillary sinus in rabbits. Histologically, 64 weeks after implantation, most of the newly formed bone in the augmented spaces had been absorbed. Histomorphometric analysis showed a significant reduction in the area of bone and a significant increase in the area of bone marrow. There was no substantial change in the area of deproteinised bone particles. We conclude that deproteinised bone particles do not absorb with time and that the newly formed bone in the augmented space after implantation is not stable in the long-term.
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