Local elastic modulus of atherosclerotic lesions of rabbit thoracic aortas and its relation to histology

T. Matsumoto, H. Abe, T. Ohashi, Y. Kato, Masaaki Sato

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Local elastic modulus of atherosclerotic lesions was measured by a pipette aspiration method in thoracic aortas of male Japanese White rabbits fed cholesterol diet for 8, 16, and 24 weeks. Local elastic modulus of the atherosclerotic lesion in the aortic arch was 26.9±2.4 kPa (mean±SEM), 33.1±1.9, and 47.5±3.9 for the 8-, 16-, and 24-week groups, respectively, while that of normal tissue was 38.2±1.7 kPa, indicating that the atherosclerotic lesion is softer than the normal tissue at its initial stage, and then gets stiffer with the progression of the disease. Histological observation showed that the initial lesion was mainly composed of foam cells and the stiffening accompanied the appearance of smooth muscle cells in the sub-intimal region. These results suggest that change in mechanical properties of atherosclerotic lesion is not simple and has a close correlation with its histology.

本文言語English
ホスト出版物のタイトルAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
出版社IEEE
ページ数1
ISBN(印刷版)0780356756
出版ステータスPublished - 1999 12月 1
イベントProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
継続期間: 1999 10月 131999 10月 16

出版物シリーズ

名前Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
1
ISSN(印刷版)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period99/10/1399/10/16

ASJC Scopus subject areas

  • 信号処理
  • 生体医工学
  • コンピュータ ビジョンおよびパターン認識
  • 健康情報学

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