Liver targeting of plasmid DNA with a cationized pullulan for tumor suppression

M. Yamamoto, J. Jo, K. Matsumoto, T. Nakamura, Y. Tabata

研究成果: Conference contribution

抄録

The preparation of a non-viral gene carrier to specifically enhance the gene expression of plasmid DNA of NK4 in the liver was discussed. An experimental mouse model of liver metastasis was prepared by intravenous injection of RLmale 1 lymphoma cells. The mouse survival and serum glutamic pyruvic transaminase (GPT) activity were examined at different time intervals. It was observed that when the in vitro gene expression was examined in the presence of asialofetuin, the expression level was suppressed for all the complexes. It was also observed that the survival of mouse bearing RL male 1 cells was prolonged only by injection of NK4 plasmid DNA complex with spermine-pullulan.

本文言語English
ホスト出版物のタイトルTransactions - 7th World Biomaterials Congress
ページ1806
ページ数1
出版ステータスPublished - 2004
イベントTransactions - 7th World Biomaterials Congress - Sydney, Australia
継続期間: 2004 5 172004 5 21

出版物シリーズ

名前Transactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period04/5/1704/5/21

ASJC Scopus subject areas

  • Engineering(all)

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