Liver injury suppressing compounds from avocado (Persea americana)

Hirokazu Kawagishi, Yuko Fukumoto, Mina Hatakeyama, Puming He, Hirokazu Arimoto, Takaho Matsuzawa, Yasushi Arimoto, Hiroyuki Suganuma, Takahiro Inakuma, Kimio Sugiyama

研究成果: Article

58 引用 (Scopus)

抜粋

To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

元の言語English
ページ(範囲)2215-2221
ページ数7
ジャーナルJournal of Agricultural and Food Chemistry
49
発行部数5
DOI
出版物ステータスPublished - 2001 9 26
外部発表Yes

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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  • これを引用

    Kawagishi, H., Fukumoto, Y., Hatakeyama, M., He, P., Arimoto, H., Matsuzawa, T., Arimoto, Y., Suganuma, H., Inakuma, T., & Sugiyama, K. (2001). Liver injury suppressing compounds from avocado (Persea americana). Journal of Agricultural and Food Chemistry, 49(5), 2215-2221. https://doi.org/10.1021/jf0015120