Lipid peroxide-DNA adducts

Seon Hwa Lee, Ian A. Blair

研究成果: Chapter

4 被引用数 (Scopus)

抄録

Increased production of reactive oxygen species during oxidative stress can initiate the formation of lipid hydroperoxides, which undergo homolytic decomposition to the α, β-unsaturated aldehydic bifunctional electrophiles, 4-oxo-2(E)- nonenal (ONE), 4-hydroxy-2(E)-nonenal (HNE), 4-hydroperoxy-2(E)-nonenal (HPNE), and malondialdehyde (MDA). Excessive lipid hydroperoxides can also be derived from the up-regulation of lipoxygenases (LOXs) and cyclooxygenases (COXs). Intracellular generation of the bifunctional electrophiles can then result in the formation of glutathione (GSH), protein, and DNA adducts. The analysis of lipid hydroperoxide-derived DNA adducts, such as ONE-derived heptanone-etheno DNA (HεDNA) adducts, can facilitate molecular epidemiology studies by providing insight into the amount of a genotoxin that has reached the DNA of the tissue under study. In addition, HεDNA adducts that are repaired and excreted in the urine can be used as specific biomarkers of lipid peroxidation-mediated DNA damage.

本文言語English
ホスト出版物のタイトルChemical Carcinogenesis
編集者Trevor Penning
ページ227-244
ページ数18
DOI
出版ステータスPublished - 2011 12 1

出版物シリーズ

名前Current Cancer Research
6
ISSN(印刷版)0940-0745

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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