Lipid bilayer array for simultaneous recording of ion channel activities

Ayumi Hirano-Iwata, Tomohiro Nasu, Azusa Oshima, Yasuo Kimura, Michio Niwano

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

This paper describes an array of stable and reduced-solvent bilayer lipid membranes (BLMs) formed in microfabricated silicon chips. BLMs were first vertically formed simultaneously and then turned 90° in order to realize a horizontal BLM array. Since the present BLMs are mechanically stable and robust, the BLMs survive this relatively tough process. Typically, a ∼60 yield in simultaneous BLM formation over 9 sites was obtained. Parallel recordings of gramicidin channel activities from different BLMs were demonstrated. The present system has great potential as a platform of BLM-based high throughput drug screening for ion channel proteins.

本文言語English
論文番号023702
ジャーナルApplied Physics Letters
101
2
DOI
出版ステータスPublished - 2012 7 9

ASJC Scopus subject areas

  • 物理学および天文学(その他)

フィンガープリント

「Lipid bilayer array for simultaneous recording of ion channel activities」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル