Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells

Nao Inoue, Naomi Yamano, Kotaro Sakata, Keisuke Arao, Takashi Kobayashi, Toshihiro Nagao, Yuji Shimada, Koji Nagao, Teruyoshi Yanagita

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The effect of linoleic acid-menthyl ester (LAME) on lipid metabolism were assessed in HepG2 cells. It is well known that high level of apolipoprotein (apo) B100 in the serum is risk for atherosclerosis. Although linoleic acid (LA) treatment and LA plus L-mentol treatment increased apo B100 secretion, LAME treatment significantly decreased apo B100 secretion in HepG2 cells compared with control medium. The hypolipidemic effect of LAME was attributable to the suppression of triglyceride synthesis in HepG2 cells. It is also known that the risk of coronary heart disease is negatively related to the concentration of serum apo A-1. In the present study, LAME treatment increased apo A-1 secretion as compared with LA treatment in HepG2 cells. These results suggest that mentyl-esterification of fatty acids may be beneficial in anti-atherogenic dietary therapy.

本文言語English
ページ(範囲)171-175
ページ数5
ジャーナルJournal of oleo science
58
4
DOI
出版ステータスPublished - 2009
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)

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