Ligand-induced structural changes in a membrane-reconstituted ion channel observed with atomic force microscopy

Youichi Shinozaki, Aya Tanaka, Nahoko Kasai, Keiichi Torimitsu, Koji Sumitomo

研究成果: Article査読

7 被引用数 (Scopus)

抄録

We investigated structural changes in ligand-gated ion channel proteins reconstituted into supported lipid bilayers. The ion channels' extracellular parts were highly dynamic and exhibited agonist-induced changes, which were inhibited by antagonists. Our data demonstrate that, by using small exogenously applied compounds (i.e., ligands), ion channel proteins reconstituted into supported lipid bilayers on a substrate can be controlled.

本文言語English
論文番号027001
ジャーナルApplied Physics Express
7
2
DOI
出版ステータスPublished - 2014 2月

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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