Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea

Tomokazu Ohshiro, Yasufumi Emori, Kaoru Saigo

研究成果: Article査読

50 被引用数 (Scopus)

抄録

Spatially and temporally regulated activity of Branchless/Breathless signaling is essential for trachea development in Drosophila. Early ubiquitous breathless (btl) expression is controlled by binding of Trachealess/Tango heterodimers to the btl minimum enhancer. Branchless/Breathless signaling includes a Sprouty-dependent negative feedback loop. We show that late btl expression is a target of Branchless/Breathless signaling and hence, Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells. Branchless/Breathless signaling activates MAP-kinase, which in turn, activates late btl expression and destabilizes Anterior-open, a repressor for late btl expression. Biochemical and genetic analysis indicated that the minimum btl enhancer includes binding sites of Anterior-open.

本文言語English
ページ(範囲)3-11
ページ数9
ジャーナルMechanisms of Development
114
1-2
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 胎生学
  • 発生生物学

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