Leydig cell tumor of the ovary associated with endometrial carcinoma and containing 17β-hydroxysteroid dehydrogenase

Ryo Ichinohasama, Shinichi Teshima, Kiyozo Kishi, Kiyoshi Mukai, Ryuichiro Tsunematsu, Hiroko Ishii-Ohba, Yukio Shimosato

研究成果: Article査読

17 被引用数 (Scopus)

抄録

A case of ovarian Leydig cell tumor associated with adenocarci-noma of the endometrium in a 66-year-old woman is described herein, the eighth such case published. Clinically, both masculinizing and feminizing symptoms were observed: an increase in facial hair growth, slight baldness, clitoromegaly, and postmenopausal genital bleeding. Three biopsies of the endometrium during a 5-month preoperativc period showed atypical hyperplasia. Surgically resected material contained a Leydig cell tumor of the left ovary and focal adenocarcinoma in atypical hyperplasia of the endometrium. Serum levels of androgens and estrogens measured by radioimmunoassay decreased after removal of the tumor. Immunohistochemical studies revealed that the Leydig cell tumor contained testosterone, estrogens, and 17β-hydroxysteroid dehydrogenase (HSD) in the cytoplasm. This is the first report of a Leydig cell tumor in which the localization of 17β-HSD was demonstrated immunohisto-chemically.

本文言語English
ページ(範囲)64-71
ページ数8
ジャーナルInternational Journal of Gynecological Pathology
8
1
DOI
出版ステータスPublished - 1989 3月
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 産婦人科学

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