TY - JOUR
T1 - Leydig cell tumor of the ovary associated with endometrial carcinoma and containing 17β-hydroxysteroid dehydrogenase
AU - Ichinohasama, Ryo
AU - Teshima, Shinichi
AU - Kishi, Kiyozo
AU - Mukai, Kiyoshi
AU - Tsunematsu, Ryuichiro
AU - Ishii-Ohba, Hiroko
AU - Shimosato, Yukio
PY - 1989/3
Y1 - 1989/3
N2 - A case of ovarian Leydig cell tumor associated with adenocarci-noma of the endometrium in a 66-year-old woman is described herein, the eighth such case published. Clinically, both masculinizing and feminizing symptoms were observed: an increase in facial hair growth, slight baldness, clitoromegaly, and postmenopausal genital bleeding. Three biopsies of the endometrium during a 5-month preoperativc period showed atypical hyperplasia. Surgically resected material contained a Leydig cell tumor of the left ovary and focal adenocarcinoma in atypical hyperplasia of the endometrium. Serum levels of androgens and estrogens measured by radioimmunoassay decreased after removal of the tumor. Immunohistochemical studies revealed that the Leydig cell tumor contained testosterone, estrogens, and 17β-hydroxysteroid dehydrogenase (HSD) in the cytoplasm. This is the first report of a Leydig cell tumor in which the localization of 17β-HSD was demonstrated immunohisto-chemically.
AB - A case of ovarian Leydig cell tumor associated with adenocarci-noma of the endometrium in a 66-year-old woman is described herein, the eighth such case published. Clinically, both masculinizing and feminizing symptoms were observed: an increase in facial hair growth, slight baldness, clitoromegaly, and postmenopausal genital bleeding. Three biopsies of the endometrium during a 5-month preoperativc period showed atypical hyperplasia. Surgically resected material contained a Leydig cell tumor of the left ovary and focal adenocarcinoma in atypical hyperplasia of the endometrium. Serum levels of androgens and estrogens measured by radioimmunoassay decreased after removal of the tumor. Immunohistochemical studies revealed that the Leydig cell tumor contained testosterone, estrogens, and 17β-hydroxysteroid dehydrogenase (HSD) in the cytoplasm. This is the first report of a Leydig cell tumor in which the localization of 17β-HSD was demonstrated immunohisto-chemically.
KW - 17β-hydroxysteroid dehydrogenase
KW - Endometrial carcinoma
KW - Estrogens
KW - Leydig cell tumor of the ovary
KW - Testosterone
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U2 - 10.1097/00004347-198903000-00008
DO - 10.1097/00004347-198903000-00008
M3 - Article
C2 - 2707954
AN - SCOPUS:0024555881
VL - 8
SP - 64
EP - 71
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
SN - 0277-1691
IS - 1
ER -