Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease

Hiroyuki Arai, Virginia M.Y. Lee, William D. Hill, Barry D. Greenberg, John Q. Trojanowski

研究成果: Article査読

44 被引用数 (Scopus)

抄録

To assess the contribution of Alzheimer's disease amyloid proteins to cortical and substantia nigra Lewy bodies (LBs), regions of postmortem brain rich in intraneuronal LBs were examined immunohistochemically. Antibodies to epitopes in domains outside the amyloidogenic beta-amyloid peptide (BAP) in BAP precursor proteins (BAPPs) as well as to the BAP itself were used as probes. These studies showed that only BAPP epitopes outside the BAP were present in substantia nigral and cortical LBs. Thus, non-amyloidogenic domains of BAPPs may be associated with intraneuronal inclusions comprised of neurofilament proteins.

本文言語English
ページ(範囲)386-390
ページ数5
ジャーナルBrain research
585
1-2
DOI
出版ステータスPublished - 1992 7月 10
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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