Leucomyosuppressin, a novel insect neuropeptide, inhibits evoked transmitter release at the mealworm neuromuscular junction

Daisuke Yamamoto, Sachiyo Ishikawa, G. Mark Holman, Ronald J. Nachman

    研究成果: Article査読

    17 被引用数 (Scopus)

    抄録

    The action of leucomyosuppressin (LMS: pGlu-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2) on the glutamate-mediated neuromuscular transmission in the mealworm, Tenebrio molitor, was studied by the microelectrode current-clamp and voltage-clamp techniques. Submicromolar concentrations of LMS reversibly attenuate evoked release of transmitter from the motor nerve terminals, as evidenced by a decrease in the quantum content estimated by the number of failures of extracellular EPSPs. LMS has no effect on the glutamate-induced depolarization. Possible intracellular mediators for the LMS action are discussed.

    本文言語English
    ページ(範囲)137-142
    ページ数6
    ジャーナルNeuroscience Letters
    95
    1-3
    DOI
    出版ステータスPublished - 1988 12月 19

    ASJC Scopus subject areas

    • 神経科学(全般)

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