Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea

Jang Ja Hong, Kuk Hyun Shin, Soon Sung Lim, Jong Hwan Kwak, Ok Pyo Zee, Kenji Ishihara, Noriyasu Hirasawa, Toshio Seyama, Kazuo Ohuchi

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Effects of compounds isolated from medicinal plants in Korea on prostaglandin E2 (PGE2) production in rat peritoneal macrophages were examined, and mechanism of action of the active constituents was analyzed. The active constituents were as follows; tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis, platycodin D isolated from the roots of Platycodon grandiflorum, imperatorin isolated from the roots of Angelica dahurica, and hyperin isolated from the roots of Acanthopanax chiisanensis. These compounds inhibit the induction of cyclooxygenase-2 (COX-2), thus inhibiting PGE2 production. The chemically synthesized chalcone derivative, 2′-hydroxy-4′-methoxychalcone, also inhibits PGE2 production by suppressing COX-2 induction. In contrast, taiwanin C isolated from the roots of Acanthopanax chiisanensis inhibited PGE2 production by direct inhibition of COX-1 and COX-2.

本文言語English
ページ(範囲)195-202
ページ数8
ジャーナルInflammation and Allergy - Drug Targets
7
3
DOI
出版ステータスPublished - 2008 9 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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