LDL-apheresis improves peripheral arterial occlusive disease with an implication for anti-inflammatory effects

Shuzo Kobayashi, Hidekazkeu Moriya, Kyouko Maesato, Kouji Okamoto, Takayasu Ohtake

研究成果: Article査読

34 被引用数 (Scopus)


Although it is known that LDL-apheresis improves ischemic limb seen in patients with peripheral arterial occlusive disease (PAOD), anti-inflammatory effects are not well known. We studied whether or not serum or plasma levels of high sensitivity C-reactive protein (hsCRP), monocyte chemoatractant protein-1 (MCP-1), or fibrinogen could contribute to favorable effects for ischemic limbs after LDL-apheresis. Twenty-eight patients with PAOD (24 men, 4 women) were enrolled in our study. LDL-apheresis was performed 10 times (treated plasma of 3,000 ml) for 5 weeks. Serum levels of logarithmically transformed values of hsCRP significantly decreased from 3.666 ± 0.126 to 3.482 ± 0.139 ng/ml before and after a single session of LDL-apheresis (P < 0.001). Serum levels of MCP-1 decreased from 233 ± 17.5 to 187 ± 13.5 pg/ml before and after LDL-apheresis (P < 0.05). Likewise, plasma fibrinogen levels statistically decreased from 196 ± 9.82 to 159 ± 9.60 mg/dl (P < 0.001). Overall rates of improvement including foot dullness or numbness, and double folds increase in walking distance were 82.1% 3 months after a completion of LDL-apheresis, while gangrene was only improved 14.3%. Intermittent claudication improved in 53.6%. The favorable actions of LDL-apheresis might include anti-inflammatory effects. To avoid amputation, LDL-apheresis should be applied for patients with PAOD at an early stage of the disease process and may be applicable for patients with atherosclerotic cardiovascular disorders.

ジャーナルJournal of Clinical Apheresis
出版ステータスPublished - 2005 12

ASJC Scopus subject areas

  • Hematology

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