Lack of histamine alters gastric mucosal morphology: Comparison of histidine decarboxylase-deficient and mast cell-deficient mice

Eiji Nakamura, Takashi Kataoka, Kazuharu Furutani, Keisuke Jimbo, Takeshi Aihara, Satoshi Tanaka, Atsushi Ichikawa, Hiroshi Ohtsu, Susumu Okabe

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Histamine plays an important role in the regulation of gastric acid secretion; however, its role in maintenance of gastric morphology remains unclear. To clarify the necessity of histamine for gastric mucosal development and maintenance, we evaluated two different kinds of mice that lacked either mast cells (one of the gastric histamine-producing cell types) or histidine decarboxylase (HDC; a histamine-synthesizing enzyme). Measurements of stomach weight, intragastric pH, mucosal histamine levels, as well as serum gastrin and albumin levels were performed in mice. Gastric mucosal appearance was examined by immunohistochemical techniques. Although gastric mucosal histamine levels in mast cell-deficient mice were half of those observed in the wild-type mice, intragastric pH, serum gastrin levels, and gastric morphology at 12 mo were unchanged compared with the wild-type mice. In contrast, HDC-deficient mice possessed no detectable gastric histamine, but did exhibit hypergastrinemia, as well as marked increases in intragastric pH and stomach weight compared with the wild-type mice. Histological analysis revealed that 9-mo-old HDC-deficient mice demonstrated hyperplasia in the oxyntic glandular base region, as well as increased numbers of parietal and enterochromaffin-like cells. These results indicate that enterochromaffin-like cell-derived histamine is potentially involved in gastric mucosal morphology regulation.

本文言語English
ページ(範囲)G1053-G1061
ジャーナルAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
287
5 50-5
DOI
出版ステータスPublished - 2004 11

ASJC Scopus subject areas

  • 生理学
  • 肝臓学
  • 消化器病学
  • 生理学(医学)

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