Lack of efficacy of high-dose intravenous immunoglobulin treatment of severe thrombocytopenia in patients with secondary dengue virus infection

Efren M. Dimaano, Mariko Saito, Shoko Honda, Edna A. Miranda, Maria T.G. Alonzo, Myra D. Valerio, Cynthia A. Mapua, Shingo Inoue, Atsushi Kumaori, Ronald Matias, Filipinas F. Natividad, Kazunori Oishi

研究成果: Article査読

45 被引用数 (Scopus)

抄録

Because most cases of secondary dengue virus infection are associated with an increased level of platelet-associated IgG, a high dose of intravenous immunoglobulin (IVIG) may have an effect on the development of severe thrombocytopenia in this disease. A randomized, controlled study was conducted with two treatment groups consisting of a treatment (IVIG) group (n = 15) and a non-treatment (non-IVIG) group (n = 16) to determine whether a high dose of IVIG is effective in hastening the recovery from thrombocytopenia in patients with secondary dengue virus infection. No significant difference was found in the baseline demographic data between the two groups. No adverse effect of IVIG was observed, but no effect in hastening the recovery of platelet counts was found in patients with secondary dengue infections. The lack of efficacy of IVIG suggests that platelet clearance by macrophages through Fc γ receptors is not a primary mechanism in this disease.

本文言語English
ページ(範囲)1135-1138
ページ数4
ジャーナルAmerican Journal of Tropical Medicine and Hygiene
77
6
DOI
出版ステータスPublished - 2007 12
外部発表はい

ASJC Scopus subject areas

  • 寄生虫科
  • ウイルス学
  • 感染症

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