抄録
Light-addressable potentiometric sensors (LAPS) consisting of a p-Si-SiO2 and p-Si-SiO2-Au structure, respectively, have been tested for a label-free electrical detection of DNA (deoxyribonucleic acid) hybridization. Three different strategies for immobilizing single-stranded probe DNA (ssDNA) molecules on a LAPS surface have been studied and compared: (a) immobilization of thiol-modified ssDNA on the patterned Au surface via gold-thiol bond, (b) covalent immobilization of amino-modified ssDNA onto the SiO2 surface functionalized with 3-aminopropyltriethoxysilane and (c) layer-by-layer adsorption of negatively charged ssDNA on a positively charged weak polyelectrolyte layer of poly(allylamine hydrochloride).
本文言語 | English |
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ページ(範囲) | 755-758 |
ページ数 | 4 |
ジャーナル | Procedia Engineering |
巻 | 87 |
DOI | |
出版ステータス | Published - 2014 |
外部発表 | はい |
イベント | 28th European Conference on Solid-State Transducers, EUROSENSORS 2014 - Brescia, Italy 継続期間: 2014 9月 7 → 2014 9月 10 |
ASJC Scopus subject areas
- 工学(全般)