L-glutamate as an excitatory transmitter at the neuromuscular junction of a beetle larva

Daisuke Yamamoto, Hiroshi Washio

    研究成果: Article査読

    14 被引用数 (Scopus)

    抄録

    The effects of L-glutamate and acetylcholine on the ventral muscle fibres of the larval mealworm Tenebrio molitor were studied by means of microelectrodes. Bath application of L-glutamate at concentrations higher than 1 × 10 4M suppressed excitatory postsynaptic potentials (EPSPs) and evoked both a depolarisation and a reduction in the input resistance of the muscle fibre. In contrast, acetylcholine chloride (up to 1 mM) had no effect at all. Circumscribed spots could be detected on the fibre surface where iontophoretic applications of L-glutamate caused transient depolarizations (glutamate potentials). Focal extracellular recordings revealed that the glutamate sensitive spots were identical with synaptic sites. The reversal potentials of the EPSP and the L-glutamate potential were identical. These results are compatible with the hypothesis that L-glutamate is an excitatory transmitter at the neuromuscular junction.

    本文言語English
    ページ(範囲)253-256
    ページ数4
    ジャーナルJournal of Insect Physiology
    26
    4
    DOI
    出版ステータスPublished - 1980 1月 1

    ASJC Scopus subject areas

    • 生理学
    • 昆虫科学

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