Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials

Japanese Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Neuroimaging Initiative

研究成果: Article査読

50 被引用数 (Scopus)

抄録

Introduction: We conducted Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) and compared the basic characteristics and progression profiles with those of ADNI in North America. Methods: A total of 537 Japanese subjects with normal cognition, late amnestic mild cognitive impairment (LMCI), or mild Alzheimer's disease (AD) were enrolled using the same criteria as ADNI. Rates of changes in representative cognitive or functional measures were compared for amyloid positron emission tomography- or cerebrospinal fluid amyloid β(1–42)-positive LMCI and mild AD between J-ADNI and ADNI. Results: Amyloid positivity rates were significantly higher in normal cognition of ADNI but at similar levels in LMCI and mild AD between J-ADNI and ADNI. Profiles of decline in cognitive or functional measures in amyloid-positive LMCI in J-ADNI (n = 75) and ADNI (n = 269) were remarkably similar, whereas those in mild AD were milder in J-ADNI (n = 73) compared with ADNI (n = 230). Discussion: These results support the feasibility of bridging of clinical trials in the prodromal stage of AD between Asia and western countries.

本文言語English
ページ(範囲)1077-1087
ページ数11
ジャーナルAlzheimer's and Dementia
14
8
DOI
出版ステータスPublished - 2018 8月

ASJC Scopus subject areas

  • 疫学
  • 健康政策
  • 発達神経科学
  • 臨床神経学
  • 老年医学
  • 精神医学および精神衛生
  • 細胞および分子神経科学

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