Isolation and structure determination of lysiformine from bacteria associated with marine sponge Halichondria okadai

Sou Kikuchi, Kayo Okada, Yuko Cho, Shinichiro Yoshida, Eunsang Kwon, Mari Yotsu-Yamashita, Keiichi Konoki

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Marine sponge Halichondria okadai is a source of numerous toxic secondary metabolites, which are considered as products of the symbiotic species associated with the sponge. In this study, we tested 720 culture conditions and purified 48 sponge-associated microbes. The ethyl acetate extract from the liquid culture of each species was tested for cytotoxicity, hemolytic activity, and brine shrimp lethal activity. Lysiformine (1) was isolated from Lysinibacillus fusiformis and its structure was determined by HRMS and NMR.

本文言語English
ページ(範囲)3742-3747
ページ数6
ジャーナルTetrahedron
74
27
DOI
出版ステータスPublished - 2018 7 5

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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