Isolation and primary structure of endorphin from salmon pituitary glands

Hiroshi Kawauchi, Makoto Tubokawa, Koji Muramoto

    研究成果: Article査読

    42 被引用数 (Scopus)

    抄録

    Endorphin has been isolated from an acid acetone extract of the pituitary of the salmon Oncorhynchus keta by ion exchange chromatography and gel filtration. Sequence analysis revealed it to be a nonacosapeptide with following primary structure: Ac-Tyr-Gly-Gly-Phe-Met-Lys-Pro-Tyr-Thr-Lys-Gln-Ser-His-Lys-Pro-Leu-Ile-Thr-Leu-Leu-Lys-His- Ile-Thr-Leu-Lys-Asn-Glu-Gln-OH. It appears that the amino terminal segment which is necessary for analgesic activity is conserved through the evolution of vertebrate except for the blocking of the amino terminal of salmon endorphin.

    本文言語English
    ページ(範囲)1249-1254
    ページ数6
    ジャーナルBiochemical and biophysical research communications
    88
    4
    DOI
    出版ステータスPublished - 1979 6 27

    ASJC Scopus subject areas

    • 生物理学
    • 生化学
    • 分子生物学
    • 細胞生物学

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