Irsogladine is a potent inhibitor of angiogenesis

Yasufumi Sato, Akio Morimoto, Akira Kiue, Kazuki Okamura, Ryoji Hamanaka, Kimitoshi Kohno, Michihiko Kuwano, Toshiie Sakata

研究成果: Article査読

39 被引用数 (Scopus)

抄録

We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.

本文言語English
ページ(範囲)155-158
ページ数4
ジャーナルFEBS Letters
322
2
DOI
出版ステータスPublished - 1993 5 10
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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