Ion permeation and selectivity of squid axon sodium channels modified by tetramethrin

Daisuke Yamamoto, Jay Z. Yeh, Toshio Narahashi

    研究成果: Article査読

    14 被引用数 (Scopus)

    抄録

    The pyrethroid tetramethrin greatly prolongs the sodium current during step depolarization and the sodium tail current associated with step repolarization of the squid axon membrane. Non-linear current-voltage relationships for the sodium tail current were analyzed to assess the open sodium channel properties which included the permeation of various cations, calcium block and cation selectivity. Tetramethrin had no effect on any of these properties. It was concluded that tetramethrin modifies the sodium channel gating machinery without affecting the pore properties.

    本文言語English
    ページ(範囲)193-197
    ページ数5
    ジャーナルBrain research
    372
    1
    DOI
    出版ステータスPublished - 1986 4 30

    ASJC Scopus subject areas

    • 神経科学(全般)
    • 分子生物学
    • 臨床神経学
    • 発生生物学

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